Long-term post-trial follow-up of participants in randomised trials: lessons learned from the mrc / bhf heart protection study (HPS)
نویسندگان
چکیده
Introduction Treatment effects may be significantly underestimated by analyses restricted to the relatively brief intervention phase of a randomised trial, and effects on cancer may only emerge during prolonged follow-up. In HPS, posttrial follow-up for non-fatal events was largely achieved via annual postal questionnaires, and the methods used may help inform the design of subsequent similar studies.
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